葫芦素B

分析标准品,HPLC≥97%

Cucurbitacin B

CAS号：6199-67-3

分子式：C32H46O8

分子量：558.71

MDL：MFCD07778083

产品介绍

熔点：184-186℃

沸点：699.3℃ at 760 mmHg

比旋光度：D25 +88° (c = 1.55 in ethanol)

外观：白色晶体

溶解性：易溶于氯仿

储存条件：2-8℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(25篇)

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21. [IF=3.391] Jiaxin Xu et al."Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity."Arch Biochem Biophys. 2020 May;684:108314

20. [IF=1.98] Yanting Chai et al."Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells."Med Sci Monitor. 2018; 24: 9251–9258

19. [IF=2.439] Wenjing Ma et al."Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia."J Pharmacol Sci. 2019 Apr;139:304

18. [IF=3.205] Zhibin Wang et al."Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets."J Chromatogr B. 2017 Oct;1065-1066:63

17. [IF=3.267] Pengfei Liu et al."Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer."Molecules. 2019 Jan;24(3):647

16. [IF=3.417] Fen  Cai et al."Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells."Oncol Rep. 2016 Aug;36(2):1180-1186

15. [IF=4.784] Shanshan Qin et al."Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme."Mol Carcinogen. 2018 Jun;57(6):687-699

14.  Liu, Xuewen, et al. "Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells." Oncology reports 38.1 (2017): 271-278.https:##doi.org/10.3892/or.2017.5648

13.  Qin, Shanshan, et al. "Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme." Molecular carcinogenesis 57.6 (2018): 687-699.

12.  Ma, Wenjing, et al. "Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t (8; 21) acute myeloid leukemia." Journal of pharmacological sciences 139.4 (2019): 304-310.https:##doi.org/10.1016/j.jphs.2018.12.010

11.  Liu, Pengfei, et al. "Cucurbitacin B induces the lysosomal degradation of EGFR and suppresses the CIP2A/PP2A/Akt signaling Axis in Gefitinib-resistant non-small cell lung Cancer." Molecules 24.3 (2019): 647.647; https:##doi.org/10.3390/molecules24030647

10.  Xu, Jiaxin, et al. "Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity." Archives of biochemistry and biophysics 684 (2020): 108314.https:##doi.org/10.1016/j.abb.2020.108314

9.  Chai, Yanting, et al. "Cucurbitacin B inhibits the Hippo-YAP signaling pathway and exerts anticancer activity in colorectal cancer cells." Medical science monitor: international medical journal of experimental and clinical research 24 (2018): 9251.10.12659

8.  Cai, Fen, et al. "Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells." Oncology reports 36.2 (2016): 1180-1186.https:##doi.org/10.3892/or.2016.4892

7.  张雅男  高明洁  祝文博 等. HPLC-UV法同时测定葫芦素片中葫芦素B和葫芦素E的含量[J]. 化学工程师  2018.

6.  周彤,杨书胜,罗明洲,向可,刘莹,陈森.葫芦素B通过抑制Hippo-YAP通路抑制结肠癌细胞转移的机制研究[J].湖北医药学院学报,2020,39(01):16-21+2+105.

5.  陈芳, 沈成英, 申宝德,等. 葫芦素B纳米混悬凝胶剂的制备及其体外透皮研究[J]. 解放军药学学报, 2015(1):49-52.

4.  胡瑞瑞, 张家梁, 郝海军. 葫芦素B磷脂复合物纳米结构脂质载体的制备[J]. 中成药, 2019, v.41(11):25-30.

3.  万露, 肖云芝, 程玲,等. 葫芦素B磷脂复合物制备,表征及体外抗肿瘤活性研究. 中草药.

2.  季娟丽,张云飞,司渊,刘鹏飞,钦闪闪,刘莹.葫芦素B抑制人顺铂耐药胃癌细胞的作用及机制研究[J].湖北医药学院学报,2017,36(05):386-390+403+374.

1.  程玲, 申宝德, 李娟娟,等. 外翻肠囊法研究葫芦素B胆盐磷脂混合胶束大鼠肠吸收动力学[J]. 中国中药杂志, 2015, 40(014):2876-2881.

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