川陈皮素

分析标准品,HPLC≥98%

Nobiletin

CAS号：478-01-3

分子式：C21H22O8

分子量：402.39

MDL：MFCD03273560

产品介绍

熔点：137-138℃

沸点：587.9℃at760mmHg

外观：无色晶体

溶解性：可溶于ＤＭＳＯ、氯仿和甲醇的混合溶剂，微溶于水和乙mi，不溶于石油mi。

敏感性：对热敏感

储存条件：-20℃

注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(94篇)

94. [IF=8.2] Jingwen Sun et al."Oligosaccharides, stachyose and α-dextran, as promising sucrose replacers in pectin gels for enhanced delivery of nobiletin."Food Chemistry-X.2025 Jul;29:102780

93. [IF=6.9] Manxi Wu et al."Alleviating Effects of Citrus Polymethoxyflavones on Autoimmune Thyroiditis via IL-17 Signaling Pathway."Food Frontiers.2025 Jun;:

92. [IF=1.7] Jie Gao et al."Comprehensive Investigation of Homology and Heterogeneity Between Aurantii Fructus and Aurantii Fructus Immaturus Using Chemometrics Combined with Network Pharmacology."JOURNAL OF MEDICINAL FOOD.

91. [IF=4.9] Hongjian Zhang et al."Effectively Enhancing the Physiological Activity and Sensory Quality of Whole Calamondin Puree via Yeast Fermentation."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(22):11984

90. [IF=8.5] Shengnan Wang et al."Postharvest changes in the phenolic and free volatile compound contents in Shine Muscat grapes at room temperature."FOOD CHEMISTRY.2025 Feb;465:141958

89. [IF=4.9] Yang Zhang et al."Characterization and identification of chemical components in Si-Ni-San based on UPLC-Q-Orbitrap-MS, HS-SPME-GC–MS, and HS-GC-IMS techniques."MICROCHEMICAL JOURNAL.2025 Feb;209:112718

88. [IF=4.9] Meng-ling Peng et al."Chemical and biological characterization of naturally aged GCP by using a rigorous sample collection protocol."MICROCHEMICAL JOURNAL.2025 Jan;:112728

87. [IF=6.7] Xinguang Liu et al."Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control."PHYTOMEDICINE.2025 Mar;138:156419

86. [IF=3] Chen Huang et al."A Comprehensive Quality Evaluation Strategy of Wendan Decoction Based on Qualitative, Fingerprint, and Quantitative Analyses."PHYTOCHEMICAL ANALYSIS.2025 Feb;:

85. [IF=4.9] Bingjing Xu et al."RDA-direct targeted flavonoids profiling strategy combined with fingerprinting and chemometrics for quality evaluation of Changshan Huyou flower."MICROCHEMICAL JOURNAL.2025 May;212:113204

84. [IF=7] Hongjian Zhang et al."Microbial succession and organic acid metabolism during spontaneous calamondin fermentation: The vital role of Pichia."FOOD RESEARCH INTERNATIONAL.2025 Mar;:116200

83. [IF=4.2] Liuqing Wang et al."Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein in Fusarium verticillioides."Journal of Fungi.2025 Apr;11(4):313

82. [IF=7.7] Huimin Pan et al."Two Caffeoyl-CoA O-methyltransferase-like enzyme are involved in the biosynthesis of polymethoxyflavones in Citrus reticulata ‘Chachiensis’."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 May;310:143277

81. [IF=1.3] Lili Liu et al."Inhibitory Effect of Ponkan (Citrus reticulata ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway."PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY.2024 Sep;93:2499

80. [IF=7.7] Xiaohan Yang et al."Pectin from steam explosion-treated citrus peel exhibits good emulsion properties and bioavailability-promoting effect in vitro of nobiletin."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;278:134758

79. [IF=8.5] Yunyi Chen et al."Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis."FOOD CHEMISTRY.2024 Dec;460:140460

78. [IF=4.9] Chenning Zhao et al."Integrated Metabolomic–Transcriptomic Analyses of Flavonoid Accumulation in Citrus Fruit under Exogenous Melatonin Treatment."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(12):6632

77. [IF=7] Xin Huang et al."The effects of core microorganism community on flavor compounds and active substances during the aging process of Citri Reticulatae Pericarpium."FOOD RESEARCH INTERNATIONAL.2024 Jun;:114707

76. [IF=4.3] Nawei Zhang et al."Factors affecting the formation of delayed bitterness in sweet orange (Citrus sinensis (L.) Osbeck) juice."JOURNAL OF FOOD COMPOSITION AND ANALYSIS".2024 Aug;132:106298

75. [IF=5] Zhang Zhihong et al."Synergistic modification of hot-melt extrusion and nobiletin on the multi-scale structures, interactions, thermal properties, and in vitro digestibility of rice starch."Frontiers in Nutrition".2024 May;11:

74. [IF=5.4] Yanchi Liu et al."Nobiletin enhances the antifungal activity of eugenol nanoemulsion against Penicillium italicum in both in vitro and in vivo settings."INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY".2024 Aug;420:110769

73. [IF=6.1] Jingqi Yang et al."Highly Effective Nobiletin–MPN in Yeast Microcapsules for Targeted Modulation of Oxidative Stress, NLRP3 Inflammasome Activation, and Immune Responses in Ulcerative Colitis."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY".2024;XXXX(XXX):XXX

72. [IF=3.9] Junjie Shi et al."Evaluation of chemical components and quality in Xinhui Chenpi (Citrus reticulata ‘Chachi’) with two different storage times by GC–MS and UPLC."Food Science & Nutrition".2024 Apr;:

71. [IF=4.6] Wang Hong-Ping et al."Comprehensive identifying flavonoids in Citri Reticulatae Pericarpium using a novel strategy based on precursor ions locked and targeted MS/MS analysis."Scientific Reports".2024 Apr;14(1):1-9

70. [IF=2.7] Tong Wang et al."Flavonoids from Citrus reticulata: Inhibitory activity against pathogenic fungi and biocontrol potential."PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY".2024 May;131:102250

69. [IF=6] Jianping Jiang et al."The optimization of extraction process on Quzhou Fructus Aurantii flavonoids with natural deep eutectic solvents: A comparative study between orthogonal analysis and genetic neural network."LWT-FOOD SCIENCE AND TECHNOLOGY".2024 Apr;1

68. [IF=8.4] Xiaonan Zhang et al."Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of α-glucosidase and porcine pancreatic lipase in vitro."ULTRA

67. [IF=8.8] Shiheng Chen et al."Short-term steaming during processing impacts the quality of Citri Reticulatae ‘Chachi’ peel."FOOD CHEMISTRY".2024 Jul;447:138964

66. [IF=3.4] Yanhua Jiang et al."Network pharmacology combined with lipidomics to reveal the regulatory effects and mechanisms of Kangzao granules in the hypothalamus of rats with central precocious puberty."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS".2024 May;

65. [IF=5.2] Dan Wu et al."Optimizing the Solvent Selection of the Ultrasound-Assisted Extraction of Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Phenolic Profiles and Antioxidant Activity."Foods".2024 Jan;13(3):482

64. [IF=8.8] Yuan Liu et al."Flavor characterization of Citri Reticulatae Pericarpium (Citrus reticulata ‘Chachiensis’) with different aging years via sensory and metabolomic approaches."FOOD CHEMISTRY.2024 Jun;443:138616

63. [IF=6.1] Chaowen Fan et al."Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX

62. [IF=5.6] Hai He et al."In-situ complexation of rice starch and nobiletin by extrusion alleviates ulcerative colitis and modulates dysbiosis of intestinal flora in C57BL/6 mice."Journal of Functional Foods.2023 Nov;110:105875

61. [IF=5] Tianzhu Guan et al."In vitro and in silico perspectives on the activation of antioxidant responsive element by citrus-derived flavonoids."Frontiers in Nutrition.2023; 10: 1257172

60. [IF=1.7] Zhouyi Zhang et al."Revealing the differences in phenolics in different parts of Taraxacum mongolicum using UPLC-MS/MS."Phytochemistry Letters.2023 Aug;56:13

59. [IF=9.336] Xiaonan Zhang et al."Anti-solvent precipitation for the preparation of nobiletin nano-particles under ultrasonication-cis/reverse homogenization."ULTRASONICS SONOCHEMISTRY.2023 Jun;96:106433

58. [IF=5.895] Jiebiao Chen et al."Polymethoxyflavone–Enriched Fraction from Ougan (Citrus reticulata cv. Suavissima) Attenuated Diabetes and Modulated Gut Microbiota in Diabetic KK-Ay Mice."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX

57. [IF=6.317] Lufang Chen et al."3D-QSAR studies on the structure–bitterness analysis of citrus flavonoids."Food & Function.2023 Apr;:

56. [IF=4.927] Zunli Ke et al."Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice."MOLECULES.2023 Jan;28(6):2570

55. [IF=6.443] Yi Zhang et al."Novel application of HS-GC-IMS for characteristic fingerprints and flavor compound variations in citrus reticulatae pericarpium during storage with different Aspergillus niger fermentation."Food Chemistry-X.2023 Jun;18:100653

54. [IF=9.221] Wei Lan et al."Rapid visual discrimination of Citri Reticulatae Pericarpium from different origins by fluorescent sensors based on aluminum ions and Ag nanoclusters."SENSORS AND ACTUATORS B-CHEMICAL.2023 Apr;380:133329

53. [IF=1.698] Jinyan Wu et al."Chemical Identification and Antioxidant Screening of Bufei Yishen Formula using an Offline DPPH Ultrahigh-Performance Liquid Chromatography Q-Extractive Orbitrap MS/MS."International Journal of Analytical Chemistry.2022 Oct 15;2022:142380

52. [IF=4.132] Jintao Lü et al."Network Analysis of the Herb–Drug Interactions of Citrus Herbs Inspired by the “Grapefruit Juice Effect"."ACS Omega.2022;7(40):35911–35923

51. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

50. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

49. [IF=3.949] Jiang Anze et al."Effects of Fruit Bagging on the Physiochemical Changes of Grapefruit (Citrus paradisi)."Food Quality and Safety.2022 Jul;:

48. [IF=4.996] Yuan Jie et al."Systematic characterization of the components and molecular mechanisms of Jinshui Huanxian granules using UPLC-Orbitrap Fusion MS integrated with network pharmacology."Scientific Reports.2022 Jul;12(1):1-24

47. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

46. [IF=5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology."PHYTOMEDICINE. 2022 Jul;102:154177

45. [IF=4.821] Tian Quan et al."Effective extraction methods based on hydrophobic deep eutectic solvent coupled with functional molecularly imprinted polymers: Application on quercetagetin extraction from natural medicine and blood."Microchem J. 2022 Mar;174:107076

44. [IF=4.35] Qian Yu et al."Aged Pericarpium Citri Reticulatae ‘Chachi’ Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells."Foods. 2022 Jan;11(3):273

43. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825

42. [IF=2.629] Mu Qixuan et al."Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis."Evid-Based Compl Alt. 2022;2022:1106353

41. [IF=3.361] Yanhui Zhao et al."Rapid characterization of the chemical constituents of Sanhua decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry."Rsc Adv. 2020 Jul;10(44):26109-26119

40. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788

39. [IF=4.192] Guoyuan Qi et al."Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways."J Agr Food Chem. 2019;67(18):5122–5134

38. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357

37. [IF=4.432] Wei He et al."Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity."Eur J Pharmacol. 2019 Aug;857:172456

36. [IF=4.566] Si-wei Wang et al."Nobiletin Alleviates Non-alcoholic Steatohepatitis in MCD-Induced Mice by Regulating Macrophage Polarization."Front Physiol. 2021; 12: 687744

35. [IF=5.279] Konglong Feng et al."Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats."J Agr Food Chem. 2020;68(22):6142–6153

34. [IF=6.529] Yuqi Ying et al."Pharmacokinetic-Pharmacodynamic Modeling of the Antioxidant Activity of Quzhou Fructus Aurantii Decoction in a Rat Model of Hyperlipidemia."Biomed Pharmacother. 2020 Nov;131:110646

33. [IF=6.922] Ya Wu et al."Preventive Effect of Flavonoid Extract from the Peel of Gonggan (Citrus reticulata Blanco Var. Gonggan) on CCl4-Induced Acute Liver Injury in Mice."J Inflamm Res. 2021; 14: 5111–5121

32. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223

31. [IF=7.514] Yongliang Cui et al."Development of a sensitive monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for analysing nobiletin in citrus and herb samples."Food Chem. 2019 Sep;293:144

30. [IF=9.229] Linlin Deng et al."Highly Crystalline Covalent Organic Frameworks Act as a Dual-Functional Fluorescent-Sensing Platform for Myricetin and Water, and Adsorbents for Myricetin."Acs Appl Mater Inter. 2021;13(28):33449–33463

29. [IF=3.046] Menglin Wei et al."Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity."Neurosci Lett. 2016 Mar;617:143

28. [IF=4.519] Guoyuan Qi et al."Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes."Bba-Mol Cell Biol L. 2018 Jun;1863:549

27. [IF=4.556] Wei He et al."Citrus aurantium L. and Its Flavonoids Regulate TNBS-Induced Inflammatory Bowel Disease through Anti-Inflammation and Suppressing Isolated Jejunum Contraction."Int J Mol Sci. 2018 Oct;19(10):3057

26. [IF=5.279] Li Liu et al."Structure–Activity Relationship of Citrus Polymethoxylated Flavones and Their Inhibitory Effects on Aspergillus niger."J Agr Food Chem. 2012;60(17):4336–4341

25. [IF=5.548] Ting Wu et al."Antifungal action and inhibitory mechanism of polymethoxylated flavones from Citrus reticulata Blanco peel against Aspergillus niger."Food Control. 2014 Jan;35:354

24. [IF=5.81] Zhang  Xianhua et al."Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats."Front Pharmacol. 2018 Mar;0:131

23.  Zhang X, Han L, Liu J, et al. Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats. Frontiers in Pharmacology. 2018 ;9:131. DOI: 10.3389/fphar.2018.00131. PMID: 29556193; PMCID: PMC5845165.

22.  Wang, Peng, et al. "Chemical and genetic discrimination of commercial Guangchenpi (Citrus reticulata ‘Chachi’) by using UPLC-QTOF-MS/MS based metabolomics and DNA barcoding approaches." RSC advances 9.40 (2019): 23373-23381.https:##doi.org/10.1039/C9RA0374

21.  Cui, Yongliang, et al. "Development of a sensitive monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for analysing nobiletin in citrus and herb samples." Food chemistry 293 (2019): 144-150.https:##doi.org/10.1016/j.foodchem.2

20.  He, Wei, et al. "Citrus aurantium L. and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and suppressing isolated jejunum contraction." International journal of molecular sciences 19.10 (2018): 3057.https:##doi.org

19.  He, Wei, et al. "Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity." European journal of pharmacology 857 (2019): 172456.https:##doi.org/10.1016/j.ejphar.2019.172456

18.  Feng, Konglong, et al. "Hepatic lipidomics analysis reveals the antiobesity and cholesterol-lowering effects of tangeretin in high-fat diet-fed rats." Journal of agricultural and food chemistry 68.22 (2020): 6142-6153.https:##doi.org/10.1021/acs.jafc.0c017

17.  陈袁,赵倩,康琪,周训美,彭捷.川陈皮素对非酒精性脂肪肝大鼠降肝脂作用[J].中国公共卫生,2020,36(11):1574-1578.

16.  李荣荣,赵迪,李蒙蒙,舒胜男,王佩阳,李焕茹,冯素香.基于UHPLC-Q Exactive-Orbitrap高分辨质谱研究浙贝母和陈皮主要成分在大鼠体内的代谢物[J].药物分析杂志,2020,40(08):1413-1424.

15.  莉莉,陈勇,张蒙伟,鄢红霞,高守红,陈万生.UHPLC-MS/MS法测定新冠肺炎经验方寒湿郁肺汤中11种主成分的含量[J].药学实践杂志,2021,39(02):148-151+156.

14.  张阳,姜华茂.川陈皮素对人前列腺癌DU145细胞生长的抑制作用及其机制[J].吉林大学学报(医学版),2020,46(06):1260-1266+1352.

13.  许守超, 陈屠梦, 包绍印,等. 基于响应面试验设计优选衢枳壳多指标成分工艺研究[J]. 中药材 2019年42卷11期, 2617-2621页, MEDLINE ISTIC PKU, 2020.

12.  高俊丽, 邵艳华, 李倩,等. 广陈皮及其近缘种药用植物的HPTLC研究[J]. 中国现代中药, 2015, 17(010):1020-1025.

11.  谢辉  陈亚  雷爱玲 等. SPE-HPLC-DAD法同时检测柑橘药用资源中黄烷酮类和川陈皮素成分[J]. 天然产物研究与开发  2019(8).

10.  邓可众  邓敏芝  熊英 等. HPLC法同时分析酸橙果实类药材中黄酮和香豆素类成分[J]. 中药材 2016年39卷3期  575-578页  MEDLINE ISTIC PKU  2016.

9.  李莉, 孙宜春, 庞媛媛,等. 陈皮水提物指纹图谱的化学计量学分析及与糖尿病认知功能障碍的谱效关系[J]. 中国实验方剂学杂志, 2020(1).

8.  盛钊君,葛思媛,张焜,谭永权,刘泽璇,李裕琳,谢芳英,陈小乐.新会柑胎仔与青皮、陈皮的黄酮含量分析与比较[J].食品研究与开发,2017,38(20):135-139.

7.  高喜梅, 池玉梅, 张雯,等. 指纹图谱结合一测多评法评价酸橙枳实质量的研究[J]. 中草药, 2020, v.51;No.668(09):281-289.

6.  李荣荣、赵迪、李蒙蒙、舒胜男、王佩阳、李焕茹、冯素香. 基于UHPLC-Q Exactive-Orbitrap高分辨质谱研究浙贝母和陈皮主要成分在大鼠体内的代谢物[J]. 药物分析杂志, 2020, v.40(08):86-97.

5.  崔欣悦  凌空  周明 等. 乳酸菌发酵柑橘皮的工艺研究及优化[J]. 食品研究与开发  2019  40(08):135-142.

4.  王娇  徐家怡  左雅敏 等. HPLC法同时测定五味藿香片中6种成分[J]. 中成药  2018  40(10).

3.  高喜梅  王晓凤  周冰倩 等. HPLC多波长条件下陈皮指纹图谱及"一测多评"法的建立[J]. 中药材 2019年42卷11期  2598-2602页  MEDLINE ISTIC PKU  2020.

2.  詹志斌, 邓可众, 熊英,等. 高效液相色谱法同时测定枳实中6种成分的含量[J]. 中国医院药学杂志, 2015, 35(012):1080-1082.

1.  张智敏, 聂莼, 李亚梅,等. 聚类分析结合主成分分析评价不同产地枳壳药材的一致性与差异性[J]. 亚太传统医药, 2019, 015(004):30-36.

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